Nature Reviews Genetics 17, 630 (2016). doi:10.1038/nrg.2016.93
Authors: Peter A. Jones, Jean-Pierre J. Issa & Stephen Baylin
Next-generation sequencing has revealed that more than 50% of human cancers harbour mutations in enzymes that are involved in chromatin organization. Tumour cells not only are activated by genetic and epigenetic alterations, but also routinely use epigenetic processes to ensure their escape from chemotherapy and
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