Nature Reviews Genetics 17, 585 (2016). doi:10.1038/nrg.2016.88
Authors: Walfred W. C. Tang, Toshihiro Kobayashi, Naoko Irie, Sabine Dietmann & M. Azim Surani
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a unique gene regulatory network in germline-competent cells for PGC specification. This network also initiates comprehensive epigenome resetting, including global DNA demethylation and
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