IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome

Publication date: Available online 5 August 2016
Source:Mutation Research/Reviews in Mutation Research
Author(s): Zvi Laron, Rivka Kauli, Lena Lapkina, Haim Werner
Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America.



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