EP 65. DBS-induced alpha desynchronization in the subthalamic nucleus of PD patients

Deep brain stimulation of the subthalamic nucleus (STN DBS) has developed into a standard therapy for treatment refractory stages of Parkinson's disease (PD). Oscillatory components play an important role in the functioning of the brain through the control of neuronal firing (Engel and Fries, 2010). The power of the beta-band (12–30Hz) in the STN is an informative biomarker for PD. It is reduced under L-Dopa medication and DBS (Kühn et al., 2008; Bronte-Stewart et al., 2009). However, the impact of DBS onto other oscillatory components and their relevance as PD biomarkers is less explored (Rosa et al., 2014; Beudel and Brown, 2016).

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