EP 78. Probabilistic imaging of motor projections of dentate nucleus as target structure for deep brain stimulation in tremor

As previously described (Coenen et al., 2014; Coenen et al., 2011), deep brain stimulation of dentate-rubro-thalamo-(cortical) (DRT(C)) pathway, efferent motor projection of dentate nucleus, leads to improvement of tremor symptoms. Visualization of DRT (C), as proposed by several authors (Coenen et al., 2011; Keser et al., 2015), reconstructs connections between dentate nucleus (DN) and ruber nucleus (RN) using deterministic diffusion tensor tractography. However tracer primate studies show that motor projections read spread more than classically described pathway in ruber nucleus (Dum and Strick, 2003).

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