Validity of The Timed Up and Go as A Measure of Functional Mobility in Persons with Multiple Sclerosis

Publication date: Available online 2 March 2016
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Emerson Sebastião, Brian M. Sandroff, Yvonne C. Learmonth, Robert W. Motl
ObjectiveTo examine the validity of the TUG as measure of functional mobility in persons with multiple sclerosis (MS) using a comprehensive framework based on construct validity (i.e., convergent and divergent validity).DesignCross-sectional studySettingHospital settingParticipantsCommunity-residing persons with MS (n = 47)InterventionNot applicable.Main Outcome MeasuresMain outcome measures included the Timed Up and Go Test (TUG), 25-foot walk (T25FW), six-minute walk (6MW), Multiple Sclerosis Walking Scale-12 (MSWS-12), Late Life Function and Disability Inventory, posturography evaluation, Activities-specific Balance Confidence (ABC), Symbol Digits Modalities Test (SDMT), Expanded Disability Status Scale (EDSS), and the number of steps taken per day.ResultsTUG performance was strongly-associated with other valid measures of ambulatory mobility (rs=.71-.90) and disability status (rs=.80); moderately-to-strongly associated with balance confidence (rs=.66), and weakly-associated with postural control (i.e., balance) (rs=.31). TUG performance was moderately-associated with cognitive processing speed (rs=.59), but not associated with other non-ambulatory measurement (i.e., LLFDI-UEF scores).ConclusionsOur findings support the validity of the TUG as a measure of functional mobility. This warrants its inclusion in patients' assessment alongside other valid measures of functional mobility in both clinical and research practice in persons with MS.



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