Evaluation of the effect of vitamin D on sodium fluoride–induced toxicity in reproductive functions of male rabbits

2016-03-02T14-34-17Z
Source: National Journal of Physiology, Pharmacy and Pharmacology
Basem H Elesawy, Abd Al N Rahman Alghamdy, Ahmad El-Askary, Magdi M Salih.
Background: Fluorosis is an endemic problem in many countries of the world. Aims and Objectives: To see the effect of fluoride on the reproductive system and to see the role, if any, of vitamin D analog paricalcitol on it. Materials and Methods: Sixty rabbits were divided into four equal groups. Group I was fed on standard diet, Group II vehicle-treated control, Group III on sodium fluoride (NaF) 20 mg/kg body weight, and Group IV on NaF + paricalcitol. Result: In Group III (fed on NaF) significant decrease in sperm count (P

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