Antioxidant, analgesic and anti-inflammatory activities of the leafy stems of Waltheria indica L. (Sterculiaceae)

2016-03-02T05-40-04Z
Source: Journal of Applied Pharmaceutical Science
Mouhibatou Nadège YOUGBARE-ZIEBROU, Marius LOMPO, Noufou OUEDRAOGO, Boubacar YARO, Innocent Pierre GUISSOUN.
Abstract Aim of the study: The existence of numerous side effects following the use of anti inflammatory drugs has led to the present study about Waltheria indica (Sterculiaceae), prescribed in the treatment of many inflammatory diseases component to discover phytomedicines secondary effects mitigated. Materials and methods: The chemical principles have been demonstrated by test characterization in liquid medium according the method of Ciulei (1949). In vivo, the model of edema induced by carrageenan to cause inflammation and the model of acetic acid induced pain were used to assess the anti-inflammatory and analgesic activities of the extract. In vitro, the effects of the aqueous extract on the DPPH°°radical, the lipoxygenase and lipid peroxidation has been demonstrated. Results: Phytochemical study of leafy stems of the plant showed the presence of tannins, flavonoids, sterols, triterpenes, saponins, reducing compounds, coumarins etc. In vivo, the results showed the aqueous extract and anti- edematous effects of the analgesic of the plant. In vitro, the results revealed the aqueous extract of W. indica inhibited the radical of DPPH°°, the lipoxygenase and the lipid peroxidation. Conclusion: The presence of chemical compounds and biological properties obtained justify the contribution of the plant in traditional medicine for the treatment of diseases with inflammatory component. Keywords: Medicinal plants, Waltheriaindica L., Inflammation, Analgesia, Anti -oxidants


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