Sildenafil reduces ischemia/reperfusion testicular injury after torsion/detorsion in rats

2016-03-02T05-40-04Z
Source: Journal of Applied Pharmaceutical Science
Marwa M. Abdel-Rahman, Ayman M. Mahmoud, Nevien M. Mostafa, Mohamed E. Saleh, Hassan M. Eissa.
This study was conducted to investigate the protective effects of sildenafil citrate on testicular injury after testis torsion/detorsion (T/D) in rats. Forty adult male Wistar rats were randomly allocated into four equal groups of ten rats each. Group 1 (Sham-operated); Group 2 (torsion for 2 hours and detorsion for 2 hours); Group 3, (torsion for 2 hours, sildenafil injection and detorsion for 2 hours), and Group 4 (sildenafil injection, torsion for 2 hours and detorsion for 2 hours). The levels of lipid peroxidation (P


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