Antinociceptive, anti-inflammatory and antipyretic effects of ethanolic root bark extract of Icacina senegalensis in rodents

2016-03-02T05-40-04Z
Source: Journal of Applied Pharmaceutical Science
Esien David-Oku, Godwin Christian Akuodor, Emmanuel Effiong Edet, Godknows K Ogbuji, Juliet Ifeoma Obiajunwa-Otteh, Daniel Ogbonna John Aja.
To investigate the ethanolic root bark extract of Icacina senegalensis for antinociceptive, anti-inflammatory and antipyretic activities in rats and mice. Acetic acid-induced abdominal constriction and tail immersion tests were used to evaluate the antinociceptive activity of the extract. Egg albumin and carrageenan-induced paw oedema were used to study the anti-inflammatory activity, whereas the anti-pyretic studies were evaluated on yeast and amphetamine-induced pyrexia. The root bark extract (50, 100 and 200 mg/kg) significantly (P


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