NEPHROPROTECTIVE ACTIVITY OF THE ETHANOLIC EXTRACT OF BOUGAINVILLAE SPECTABILIS LEAVES AGAINST GENTAMYCIN INDUCED RENAL DYSFUNCTION IN WISTAR RATS

2016-08-12T02-13-49Z
Source: Indo American Journal of Pharmaceutical Research
V. Thushara Bindu*, S. Nelson Kumar, C. Rajaram, P. Ranga Swamy, S. Shabana.
The current study aimed at evaluating the protective effects of Bougainvillae spectabilis (Nyctaginaceae family) on renal dysfunction of Gentamycin induced wistar albino rats using biochemical approaches. Pinitol, betacyanine, flavonoids, tannins and alkaloids are the constituents reported for B. spectabilis. Nephrotoxicity is considered a prominent side effect of Aminoglycoside antibiotic, Gentamicin. The drug was induced intra peritoneally at a dose of 80 mg/ kg body weight for 9 days. One of the main factors in for Gentamycin induced Nephrotoxicity is the Oxidative stress. Ethanolic extract of B. spectabilis decreased the increased levels of blood urea, serum creatinine, urinary protein, and extent of renal dysfunction at dose levels of 200 and 400 mg/kg body weight in wistar albino rats.


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