A REVIEW ON NOVEL APPROACH OF ANTIFUNGAL EMULGEL FOR TOPICAL DELIVERY IN FUNGAL INFECTIONS

2016-08-12T02-13-49Z
Source: Indo American Journal of Pharmaceutical Research
Jasmeen Kaur, Jotinder Kaur, Sandhya Jaiswal, Ghanshyam Das Gupta*.
Fungal infections of the skin are one of the most frequently challenged dermatological diseases in world. Topical therapy is better choice for the treatment of cutaneous infections. The key feature of topical delivery is direct approachability via skin as a target for treatment resulting to increase in bioavailability and deduction in side effects. Currently, conventional creams and gel preparations are commercially available for topical treatment. Gels have a major restraint for delivery of hydrophobic drugs. So, to overcome this constraint, an emulsion based approach is considered. Emulgels are combination of gel and emulsion technique and have a high ability to penetrate the skin. It has emerged as one of the most prevailing delivery systems for hydrophobic drugs due to their dual control release system i.e. gel and emulsion. The main objective is to develop jellified emulsion to decrease the systemic side effects and to create pronounced effect with lower doses of the drug. In recent years there has been great interest in the use of novel polymers with complex function such as emulsifier and thickeners. The gelling capacity of these compounds allows stable formulation by decreasing surface, interfacial tension resulting in increase in viscosity of aqueous phase. Various permeation enhancers can potentiate its effect. So, the present review concludes that emulgels are most promising system having major advantages on conventional systems, as a result it can be explored for topical drug delivery.


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