ANTI-CANCER ACTIVITY OF SECONDARY METABOLITES FROM BAUHINIA VARIEGATA LINN. LEAF – AN IN SILICO APPROACH

2016-08-12T02-13-49Z
Source: Indo American Journal of Pharmaceutical Research
Gayathri Gunalan *, K.Vijayalakshmi , T.Tamilvannan and Waheetha Hopper.
Plants and plant derived products are used for human healthcare since the dawn of human civilization. About 80% of modern drugs are from natural origin. Many dreadful diseases like cancer are treated using drugs of natural origin. In the present study, a medicinal plant B.variegata linn. leaves were investigated for its anti - colon cancer activity using COLO 320 cell lines. The active fractions were isolated by bioactivity guided fractionation and subjected to GC-MS analysis to identify the bioactive compounds. The aim of the present study was to identify potential lead compounds against various protein targets that are involved in colon carcinogenesis using molecular docking approach. 3D structures of compounds reported from GCMS analysis of active fractions of B.variegata were built using Chemsketch software. All the compounds analyzed exhibited anticancer, antiviral, antibacterial, antineoplastic, antidiabetic and anti-inflammatory properties. Docking studies were performed using Glide (Grid-based Ligand Docking with Energetics) Extra Precision (XP) 5.7 algorithm in Schrodinger Software Suite, 2011 analysis. Among the 33 ligands of the active fractions, eight ligands were found to have least glide score. Thus, the phytochemicals from the active fractions of B.variegata leaf was found to have appreciable anti-cancer activity.


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