FV 6. Striatal Microcircuit alterations in a mouse model of preclinical parkinsonism

During recent years, extensive studies in different genetic model systems have complemented conventional toxin-based dopamine depletion approaches and significantly advanced our pathophysiological understanding of familial Parkinson's disease (PD) from a molecular level to human clinical practice.One of the particular strengths of genetic models is that they open experimental windows to hitherto inaccessible presymptomatic periods in PD, allowing for an investigation of functional changes and adaptive mechanisms during very early phases of this complex neurodegenerative disorder.

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