FV 4. U-Fiber Density Imaging identifies specific microstructural alterations in the epileptogenic zone in individual patients with cryptogenic focal epileps

Patients with cryptogenic focal epilepsy (cFE), where conventional MRI does not show any structural lesion represent the fastest growing number of epilepsy surgery candidates in most tertiary referral centers. The absence of a visible surgical target challenges presurgical evaluation and requires complementary diagnostic methods to guide further investigations, especially intracranial EEG recordings. Here we present a new diagnostic approach, based on the quantification of regional u-fiber density to identify specific microstructural abnormalities in the epileptogenic zone of patients with cFE.

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