Reply to “Chronic hepatitis C and diabetes: More questions than answers with the new direct acting antiviral drugs?”

We thank Wynter et al. for the interest showed towards our recent review article [1] on the impact of the sustained virological response (SVR) on diabetes mellitus (DM) in patients with chronic hepatitis C. According to their data, SVR obtained by using DAA agents has negligible effect on concomitant DM; however, the number of patients considered is really too small and the follow up period too short to provide us with conclusive statements. Moreover, they suggest that improvement in insulin resistance observed in HCV+ patients cured by IFN-based therapies+ribavirin is due to the medications themselves rather than viral eradication.

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