Early Post-Hepatoportoenterostomy Predictors of Native Liver Survival in Biliary Atresia.

Objectives: Most infants with biliary atresia (BA) require liver transplantation (LT) following hepatoportoenterostomy (HPE), including those who initially clear jaundice. The aim of this study was to identify clinical and routine laboratory factors in BA infants post-HPE that predict native liver survival at 2 years. Methods: A retrospective cohort study was conducted with 217 BA patients undergoing HPE in Sydney, Australia and Toronto, Canada between January 1986-July 2009. Univariate and multivariate logistic regression using backwards-stepwise elimination identified variables at 3 months post-HPE most associated with 2-year native liver survival. Results: Significant variables (p 45 days, change in length z-scores within 3 months of HPE and center. On multivariate analysis, TB (p 35 g/L (3.5 mg/dL; AUROC 0.7633) to predict 2-year native liver survival. TB and albumin levels 3 months post-HPE defined three Groups (1: TB35 g/L; 2: TB74 [mu]mol/L) with distinct short- and long-term native liver survival rates (log-rank p

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