Τρίτη 21 Ιουνίου 2016

Response to letter to the editor regarding: “Local versus distal transplantation of human neural stem cells following chronic spinal cord injury” by Cheng et al

We thank the letter writers for their insightful comments on our article [1] and for highlighting the difficulty in creating a consistent spinal cord injury (SCI) in the rodent model. Over multiple studies [1–3], we have refined the surgical technique to be consistent and reproducible, with the senior author performing all the surgeries and utilizing computer assistance to ensure uniform impact to the spinal cords. All rats demonstrated consistent SCI after surgery upon examination using the Basso, Beattie, Bresnahan locomotor score.

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