Cytokines (IL 1β and IL 6) Responses in Non-Pregnant Does Infected With Corynebacterium Pseudotuberculosis Following Intradermal Route of Infection in Chronic State

2016-06-21T09-41-09Z
Source: International Journal of Livestock Research
Faez Firdaus Abdullah Jesse, Nur-Amirah Abdul Latif, Eric Lim Teik Chung, Lawan Adamu, Siti Aimi Sarah, Mohd Zamri-saad, Abdul Wahid Haron, Mohd Azmi Mohd Lila, Zunita Zakaria.
Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis (CLA) which commonly affects sheep and goats. The disease remains as a major disease causing economic loss to the small ruminant industries. There is little information related to responses of interleukin-1β and interleukin-6 in the chronic states. This study was designed to determine the serum concentrations of interleukin-1β and interleukin-6 (pg/mL) in non-pregnant does experimentally inoculated with Corynebacterium pseudotuberculosis via intradermal route in chronic form. Eighteen non-pregnant healthy Katjang does aged 2 years old were divided randomly into two groups. The control and the treatment groups consist of nine does each and were kept for 3 months. The control group was inoculated with PBS solution while the treatment group was inoculated intradermally with C. pseudotuberculosis. Serum samples were collected every 3 days (72 hours) for 3 months (2064 hours). The present study showed significant increase in IL-1β (278 ± 19.19 pg/mL) after 1day (24 hours) of post infection (p


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