Translating RNA sequencing into clinical diagnostics: opportunities and challenges

Nature Reviews Genetics 17, 257 (2016). doi:10.1038/nrg.2016.10

Authors: Sara A. Byron, Kendall R. Van Keuren-Jensen, David M. Engelthaler, John D. Carpten & David W. Craig

With the emergence of RNA sequencing (RNA-seq) technologies, RNA-based biomolecules hold expanded promise for their diagnostic, prognostic and therapeutic applicability in various diseases, including cancers and infectious diseases. Detection of gene fusions and differential expression of known disease-causing transcripts by RNA-seq represent some of the

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