Δευτέρα 18 Απριλίου 2016

Endogenous microRNA sponges: evidence and controversy

Nature Reviews Genetics 17, 272 (2016). doi:10.1038/nrg.2016.20

Authors: Daniel W. Thomson & Marcel E. Dinger

The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with shared microRNA (miRNA) binding sites compete for post-transcriptional control. This hypothesis has gained substantial attention as a unifying function for long non-coding RNAs, pseudogene transcripts and circular RNAs, as well as an alternative function for



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