Nature Reviews Genetics 17, 253 (2016). doi:10.1038/nrg.2016.35
Author: Darren J. Burgess
Reprogramming differentiated cells into induced pluripotent stem cells (iPSCs) holds promise for generating patient-specific cells for regenerative medicine. However, transcriptomics and DNA-methylation analyses have revealed that iPSCs typically retain a subtle molecular 'memory' of their cell-type of origin, which then favours subsequent differentiation towards the
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