Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases

Nature Reviews Genetics 17, 300 (2016). doi:10.1038/nrg.2016.28

Authors: Shengdar Q. Tsai & J. Keith Joung

CRISPR–Cas9 RNA-guided nucleases are a transformative technology for biology, genetics and medicine owing to the simplicity with which they can be programmed to cleave specific DNA target sites in living cells and organisms. However, to translate these powerful molecular tools into safe, effective clinical applications,

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