Progressive Change in Sleep over Multiple Nights of Intracranial EEG Monitoring

Intracranial EEG (icEEG) is used in patients with medically intractable epilepsy undergoing monitoring to localize the seizure onset area. Multiple studies have shown that there is an interaction between seizure occurrence, time of day, state of sleep or wakefulness, and likely circadian rhythms (Pavlova et al., 2004; Durazzo et al., 2008; Loddenkemper et al., 2011). However, the mechanism of these interactions and the structures that regulate them are not well-understood. Further, the prevalence and features of interictal epileptiform discharges and high-frequency oscillations (HFOs) in the icEEG may directly depend on patient sleep and wake state.

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