Graph theory network function in Parkinson’s disease assessed with electroencephalography

Lewy-type synucleinopathy (LTS) is established to be prominent in the cerebral cortex at mid and later stages of Parkinson's disease (PD). Alzheimer's disease (AD) pathology and vascular lesions are also present in a portion of cases. Functional imaging and quantitative electroencephalography (QEEG) studies have revealed physiologic dysfunction of widespread cortical areas. However, the manner in which cortical or subcortical pathology disrupts interaction within and between cortical areas has received little study and remains to be established.

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