Τετάρτη 10 Οκτωβρίου 2018

Walking Pace Is Associated with Lower Risk of All-Cause and Cause-Specific Mortality

Purpose Walking pace is associated with all-cause and cardiovascular disease (CVD) mortality. Whether this association extends to other health outcomes and whether it is independent of total amount of time walked are currently unknown. Therefore, the aim of this study was to investigate whether usual walking pace is associated with a range of health outcomes. Methods 318,185 UK Biobank participants (54% women) aged 40-69 years were included. Walking pace and total walking time were self-reported. The outcomes comprised: all-cause mortality as well as incidence and mortality from cardiovascular disease (CVD), respiratory disease and cancer. The associations were investigated using Cox proportional hazard models. Results Over a mean of 5.0 years [ranging from 3.3 to 7.8], 5,890 participants died, 18,568 developed CVD, 5,430 respiratory disease and 19,234 cancer. In a fully adjusted model, compared to slow pace walkers, men and women, respectively, with a brisk pace having lower risk of mortality from all-causes (HR0.79 [95% CI: 0.69; 0.90] and 0.73 [95% CI: 0.62; 0.85]), CVD (HR 0.62 [0.50; 0.76] and 0.80 [0.73; 0.88]), respiratory disease (HR 0.58 [95% CI 0.43; 0.78] and 0.66 [0.57; 0.77]), COPD (HR 0.26 [95% 0.12; 0.56] and 0.28 [0.16; 0.49]). No associations were found for all-cause cancer, colorectal, breast cancer. However, brisk walking was associated with a higher risk of prostate cancer. Conclusions Walking pace is associated with lower risk of a wide range of important health conditions, independently of overall time spent walking. ‡CCM, SG and FP contributed equally to this work and are joint first authors * JPP, NS, JMRG contributed equally to this work and are joint senior authors. CORRESPONDING AUTHOR: Professor Jason Gill, BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life, Sciences, University of Glasgow, Glasgow G12 8TA, UK. Tel: 044 (0) 141 3304201; Fax: 044 (0) 141 3305481; E-mail address: jason.gill@glasgow.ac.uk This research has been conducted using the UK Biobank Resource under Application Number 7155. The UK Biobank was supported by the Wellcome Trust, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government and the British Heart Foundation. The research was designed, conducted, analysed and interpreted by the authors entirely independently of the funding sources. The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation, and statement that results of the present study do not constitute endorsement by ACSM. CONFLICT OF INTEREST: The authors declare that they have no conflict of interest. Accepted for Publication: 12 September 2018. © 2018 American College of Sports Medicine

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