Two-Year Agility Maintenance Training Slows the Progression of Parkinsonian Symptoms

Introduction Parkinson's disease (PD) is a progressive neurodegenerative condition and it is unclear if long-term non-pharmaceutical interventions can slow the progression of motor and non-motor symptoms and lower drug dose. Methods In a randomized trial, after an initial 3-week-long, 15-session supervised high-intensity sensorimotor agility exercise (E) program designed to improve postural instability, the Exercise+Maintenance (E+M, n=19) group continued to exercise three times per week for 2 years, while E (n=16) and the no exercise and no maintenance control (C, n=20) continued habitual living. Eight outcomes were measured before and after the 3-week initial exercise program and then at 3, 6, 9, 12, 18, and 24 months in all patients. Results The Group by Time interactions (all p

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