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Prophylactic Therapy for Hereditary Angioedema.
Immunol Allergy Clin North Am. 2017 Aug;37(3):557-570
Authors: Longhurst H, Zinser E
Abstract
Long-term prophylaxis is needed in many patients with hereditary angioedema and poses many challenges. Attenuated androgens are effective in many but are limited by side effect profiles. There is less evidence for efficacy of tranexamic acid and progestagens; however, the small side effect profile makes tranexamic acid an option for prophylaxis in children and progestagens an option for women. C1 inhibitor is beneficial, but at present requires intravenous delivery and may need dose titration for maximum efficacy. Short-term prophylaxis should be considered for all procedures. New therapies are promising in overcoming many problems encountered with current options for long-term prophylaxis.
PMID: 28687109 [PubMed - in process]
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