Angiotensin-converting Enzyme Inhibitor and Other Drug-associated Angioedema.

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Angiotensin-converting Enzyme Inhibitor and Other Drug-associated Angioedema.

Immunol Allergy Clin North Am. 2017 Aug;37(3):483-495

Authors: Stone C, Brown NJ

Abstract
Nonsteroidal antiinflammatory agents, β-lactam antibiotics, non-β lactam antibiotics, and angiotensin-converting enzyme inhibitors are the most common classes of drugs that cause angioedema. Drug-induced angioedema is known to occur via mechanisms mediated by histamine, bradykinin, or leukotriene, and an understanding of these mechanisms is crucial in guiding therapeutic decisions. Nonallergic angioedema occurs in patients with genetic variants that affect metabolism or synthesis of bradykinin, substance P, prostaglandins, or leukotrienes, or when patients are taking drugs that have synergistic mechanisms. The mainstay in treatment of nonallergic drug-induced angioedema is cessation of the offending agents.

PMID: 28687104 [PubMed - in process]

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