Laser and Somatosensory Evoked Potentials in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of mainly upper and lower motor neurons (Duleep and Shefner, 2013). The diagnosis of ALS generally requires normal sensory nerve conduction studies (NCS) (Brooks et al., 2000; de Carvalho et al., 2008), and normal sensory nerve action potentials are reported in several studies (Ertekin, 1967; Fincham and Van Allen, 1964; Stålberg and Sanders, 1992). However, many other studies have shown involvement of large diameter (A-beta) sensory fibres in ALS patients using NCS (e.g., Hammad et al., 2007; Isaacs et al., 2007; Isak et al., 2016; Pugdahl et al., 2007 and 2008) and somatosensory evoked potentials (SSEPs) (Cosi et al., 1984; Bosch et al., 1985; Matheson et al., 1986; Ogata et al., 2001; Hamada et al., 2007).

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