Cognitive motor interference in multiple sclerosis: Insights from a systematic, quantitative review

Publication date: Available online 16 August 2016
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Yvonne C. Learmonth, Ipek Ensari, Robert W. Motl
ObjectivesTo synthesise the evidence for differences in cognitive motor interference (CMI) between persons with MS and healthy controls by using systematic review and meta-analysis.Data SourcesEMBASE, PubMed, Science Direct, Scopus, SPORTDiscus and Web of Science. Our focused literature search was informed by past systematic reviews of CMI during walking in MS.Study SelectionThe key terms searched involved Multiple Sclerosis, and synonyms of motor function (e.g., Gait disorders, Gait, Walking, Balance or Fall) and motor and cognitive functions (e.g., Cognitive motor interference, or Thinking).Data ExtractionFrom the 116 abstracts identified articles, 13 experimental studies were selected for final analysis and were rated based on the Quality Assessment of Diagnostic Accuracy tool. A meta-analysis was performed for all considered outcomes.Data SynthesisThe results yielded a small overall effect size (ES) of 0.08 (SE = .17; 95% CI= -0.25, 0.40; z=0.49; p>.05), and this indicated a non-significant, minimal difference in CMI between persons with MS and healthy controls. The moderator analysis for motor task (Mobility task, ES=0.22; Postural task, ES= -0.11) was not significantly different between MS and controls. The moderator analysis for cognitive task (Verbal fluency task, ES=0.66; Mental Tracking tasks, ES=0.04; Discrimination and Decision-making tasks, ES=?) resulted in a significantly difference in CMI between MS and controls (p<.05).ConclusionsWe provide evidence that overall there is minimal difference in CMI between persons with MS and healthy control participants.



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