Acute psychotic episode under isoniazid treatment: A Case Report

2016-07-25T17-20-02Z
Source: Düşünen Adam: The Journal of Psychiatry and Neurological Sciences
Gökhan Umut, Bahar Dernek, İlker Küçükparlak, Tuğba Aydın, Nesrin Karamustafalıoğlu, Fatma Nur Kesiktaş.
Each year, nearly 9 million new tuberculosis mycobacterium infection is being detected worlwide. It is mostly recommended to use isoniazid (isonicotinic acid hydrazide [INH]) in the treatment and prophylaxis of this infection by the World Health Organization. As INH is taken overdose synthesis of pyridoxal -5- phosphate and GABA are decreased and this causes cerebral excitability and seizures. In some rare cases, it is believed that isoniazid causes mania, depression, obsessive compulsive disorder and psychosis by MAO inhibitor activity or pyridoxine reduction. In this case report, a 28-year-old man with acute psychotic attack precipitated by cannabis use under INH treatment, is presented.


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