Toxic hepatitis associated with amoxicillin-clavulanic acid in a chronic viral hepatitis B patient: a case report

2016-06-30T18-08-44Z
Source: Bakırköy Tıp Dergisi
Pervin Özkan Kurtgöz, Havva Tünay, Fatma Kurban, Serkan Kurtgöz, Kasım Demir, Gürsel Acartürk.
Amoxicillin-clavulanic acid (ACA) related hepatotoxicity is among the most common causes of drug-related hepatotoxicity. Cholestatic liver injury is the most common type. Symptoms usually begin 1-4 weeks after ingestion and heal within 8 weeks. Rarely develop fulminant hepatitis and death. In this study, we present a case of a 62-year-old woman who had chronic viral hepatitis B and developed toxic hepatitis after receiving ACA treatment. When ACA was discontinued, the patients symptomps improved and her liver enzyme levels reduced to near to the normal range.


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