Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorder in a Pediatric Patient

2016-06-30T17-53-30Z
Source: Annals of Paediatric Rheumatology
Stephanie Phillips, DO, Charles Newman, MD, Austin Turner, MD, Michael Stump, MD, Katherine Silver, MD, Richard Silver, MD, Michelle Hudspeth, MD, John Lazarchick, MD.
It is estimated that approximately 90% of the adult population is infected with the Epstein Barr Virus (EBV). In states of immunosuppression, the disruption in immune regulation can manifest as lymphoproliferative disease that classically presents as a lymphoma. Rarely, EBV-driven lymphoproliferative disease can present as a mucocutaneous ulcer. While this phenomenon is becoming well documented in the adult population, cases affecting pediatric patients are lacking. In this report, we describe a case of a pediatric immunosuppressed patient presenting with an EBV-positive mucocutaneous ulcer. EBV-positive mucocutaneous ulcer in an immunosuppressed patient is an entity within the spectrum of iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPD) which closely resembles the better-categorized post-transplant lymphoproliferative disorder (PTLD). Though the concept of lymphoproliferative disorders in immunosuppressed patients has been well established, this is a unique case in a pediatric patient.


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