The role of transient receptor potential channels in hypertension and metabolic vascular damage

Intracellular Ca²⁺ homeostasis is critical for vascular function and metabolism regulation. Metabolic disorders are major risk factors for hypertension. A family of transient receptor potential (TRP) channels plays an important role in the regulation of cellular calcium signaling and cardiometabolic function. Emerging evidence indicates that TRP channels are highly implicated in the pathogenesis of hypertension and metabolic disorders. Dysfunction of TRP channels leads to hypertension and metabolic dysfunction. Activation of certain subtypes of TRP channels could attenuate metabolic vascular damage and alleviate hypertension. Therefore, elucidating the role of TRP channels in the physiological status and cardiometabolic diseases will facilitate the design of novel target therapeutics for these intractable diseases.

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