Remission in Pediatric Inflammatory Bowel Disease Correlates with Prescription Refill Adherence Rates.

Objectives: To utilize pharmacy benefit management (PBM) prescription claims data to assess refill adherence in pediatric inflammatory bowel disease (IBD) and correlate adherence with clinical outcomes in pediatric IBD. Methods: We identified 362 pediatric IBD patients seen at Washington University from 9/1/2012 to 8/31/2013 and matched them within Express Scripts' member eligibility files for clients allowing use of prescription drug data for research purposes. Maintenance IBD medication possession ratios (MPR) were determined through PBM prescription claims data and chart review. Demographic and prospectively captured physician global assessments (PGA) were retrospectively extracted from the medical record. MPR was analyzed as continuous data and also dichotomized as greater or less than 80%. Results: Among our 362 patients, we matched 228 (63%) within Express Scripts' eligibility data files. Of those, 78 patients were continuously eligible for benefits and had at least one outpatient prescription IBD medication. Their mean MPR was 0.63 +/- 0.31 (SD) and 40% had an MPR >= 80%. Patients in clinical remission had a higher mean MPR than those with an active PGA (0.72 +/- 0.28 vs. 0.51 +/- 0.32, P = 0.002) and patients whose MPR were >= 80% were more likely to have a PGA of remission than those with whose MPR were

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