Exercising small muscle groups at a time allows higher muscle specific workloads compared to whole body aerobic exercises in people with chronic obstructive pulmonary disease (COPD). Whether similar effects also occur with partitioning exercise during low load/high-repetition resistance exercises is uncertain. Purpose: To investigate the acute effects of partitioning exercise on exercise workload, exertional symptoms and quadriceps muscle fatigue during low load/high-repetition resistance exercises in people with COPD and healthy controls. Methods: We compared the acute physiological effects of single-limb (SL) versus two-limb (TL) execution of isokinetic knee-extension and of six low load/high-repetition elastic resistance exercises in 20 people with COPD (FEV1 = 38% predicted) and 15 healthy controls. Results: Among people with COPD, SL exercises resulted in higher exercise workloads during isokinetic knee-extension (17 +/- 31%, p
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