The relationship between seizures, interictal spikes and antiepileptic drugs

Interictal EEG spikes are known to be highly correlated with the presence of epilepsy (Carreňo and Lüders, 2001; Bautista, 2013; Staba et al., 2014). However, the relationship between interictal spikes and seizure occurrence is not clear. We previously reported a decrease in spike rates accompanies antiepileptic drug (AED) taper during intracranial EEG (icEEG) monitoring (Spencer et al., 2008; Goncharova et al., 2013). This observation suggests that interictal spikes reflect inhibitory and not excitatory mechanisms (Spencer et al., 2008).

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