Predictive role of brain connectivity for resective surgery in Lennox-Gastaut syndrome

Lennox-Gastaut syndrome (LGS) is a syndrome-specific disorder caused by multiple etiologies. LGS characterizes multiple types of seizure, developmental deterioration, and specific electroencephalographic (EEG) features that include bilaterally synchronized generalized sharp and wave discharges (GSWs). These GSWs may hide the primary epileptogenic areas (PEAs) due to the propagation of activity from the PEA to the contralateral hemisphere or due to build-up with synchronous electrical firing from independent bilateral epileptogenic foci via the corpus callosum or subcortical structures (Jung et al., 2005; Ono et al., 2009; Lin et al., 2012).

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