SYNTHESIS, SPECTRAL AND ANTIMICROBIAL STUDIES ON Co(II) COMPLEXES OF N-SUBSTITUTED 2-CHLORO PHENOTHIAZINES.

2016-05-05T19-36-43Z
Source: Indo American Journal of Pharmaceutical Research
Madhushree N N, Chandrashekara P G*, Umesha S.
The transition metal complexes of Co (II) has been synthesized using 2-chloro phenothiazine derivatives as main ligand and purified by recrystallization in methanol. These have been characterized by elemental analysis, IR, molar conductivity measurement, magnetic studies, TGA, UV and mass. These studies were revealed that an octahedral geometry of the type [M(L)(L1).3H2O] and [M(L)(L1).2H2O], Where M = Co(II), L is ligand, L1 is 1:10-phenathroline. All the metal complexes are mononuclear and have octahedral geometry. Synthesized metal complexes were screened for antimicrobial activities (antifungal and antibacterial) against three bacteria and three fungi using In vitro disc diffusion method. The result revealed that most of the synthesized complex compounds exhibited good antimicrobial activities.


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