SCREENING OF TABUBEIA ROSEA DC: FOR ANTITUBERCULOSIS, ANTIBACTERIAL AND ANTIOXIDANT STUDIES; AN IN VITRO APPROACH

2016-05-05T19-36-43Z
Source: Indo American Journal of Pharmaceutical Research
Suriyamurthy Anupriya, Rajamani Aravind, Kannan Elangovan, Kandasamy Murugesan*.
The aim and objective of this study, to screen phytochemical components which is responsible for antimycobacterial, antibacterial and the antioxidant activities. This study deals with the antimycobacterial activity of Tabubeia rosea against H37RV and MDR clinical isolate of Mycobacterium tuberculosis. Tuberculosis (TB) kills approximately two million peoples annually. The results revealed that 500 μg/mL of the methanolic extract possessed significant antimycobacterial activity against H37RV strain of M. tuberculosis and on the other hand, methanolic extract at 100 μg/mL inhibited the growth of clinically isolated strain of M. tuberculosis. Besides antibacterial activity was tested against 5 human pathogens such as Escherichia coli, Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus and Pseudomonas aeruginosa. Among all the pathogens, Escherichia coli was found to be highly susceptible (18 mm) was recorded at 100 μg/mL. In vitro antioxidant activities revealed that methanolic extract could be a promising source of natural antioxidants. The results confirmed traditional use of Tabubeia rosea extract to fight against tuberculosis.


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