Nature Reviews Genetics 17, 313 (2016). doi:10.1038/nrg.2016.52
Author: Darren J. Burgess
Resources for genome-scale loss-of-function screens in mammalian cells have progressed rapidly, particularly with RNA interference (RNAi)-based libraries and, more recently, with CRISPR–Cas9-based libraries. A new parallel screening study leverages the complementary strengths of each system to dissect antiviral drug mechanisms and to identify potential combination
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