Meiotic synapsis and recombination between homologs permits the formation of cross-overs that are essential for generating chromosomally balanced sperm and eggs. In mammals, surveillance mechanisms eliminate meiotic cells with defective synapsis, thereby minimizing transmission of aneuploidy. One such surveillance mechanism is meiotic silencing, the inactivation of genes located on asynapsed...
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Τρίτη 21 Νοεμβρίου 2017
DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line [Genetics]
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