Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively

Approximately 30% of patients with epilepsy continue to have disabling seizures despite treatment with multiple antiepileptic drugs (Kwan and Brodie, 2000). Of those patients with focal epilepsy that are resistant to multiple medications, resective surgery is an intervention that has been proven to reduce the seizure burden, improve the patients' quality of life, and reduce mortality rate (Wiebe et al. 2001; Sperling et al. 2016). The goal of resective epilepsy surgery is to identify and remove epileptogenic brain regions while minimizing residual neurological deficits.

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