Behavioral and neurophysiological mechanisms underlying motor skill learning in patients with post-stroke hemiparesis

Skilled actions of daily life such as reaching across a busy table to pick a coffee mug are often performed with accurate, yet fast and efficient arm movements. Such complex skilled actions require optimization of speed and accuracy; and rely on efficient planning and execution (Begliomini et al., 2014; Fang et al., 2015; Orban de Xivry et al., 2017; Stewart et al., 2013). Following a neurological insult such as stroke, skilled arm movements are greatly impaired in the paretic (weaker) arm such that task performance is slow, inaccurate and fragmented (Cirstea et al., 2003; Levin, 1996; Liu et al., 2013; Shaikh et al., 2014; Silva et al., 2014).

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