The Complications and Risk Factors Analysis of High Dose TXA Used in Spinal Correction Surgery: Data from 726 Patients Over Six Years

BACKGROUND CONTEXT: High levels of intraoperative blood loss are widely documented in spinal correction surgery, and intraoperative administration of antifibrinolytics to reduce intraoperative bleeding has gained popularity. Because of severe complications, aprotinin was forbidden in clinic, and TXA has been widely used in surgery. The effectiveness of high dose TXA has been proved in spinal correction surgery, but there is few systematic data about the complications of the high dose TXA, especially in spinal correction surgery.

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