Reply to “Low-grade intraductal carcinoma of the prostate: An idea whose time has not yet come”: Evidence-based medicine suggests that the time is now

Abstract

In the above-referenced commentary,¹ Murali Varma raises two valid concerns regarding implications for communication from the message of our study². First, introducing a term ”Atypical Intraductal Proliferation (AIP)” or “low-grade intraductal carcinoma (IDC-P)” for which there are no well-defined morphological cut-offs or criteria and, second, for the risk of overtreatment.

In this author's experience which is based on current² and previous studies,^3-6 AIPs represent significant lesions and must be distinguished from HGPIN. Morphologically, the vast majority of AIPs present with cribriform morphology which have been increasingly recognized as significant lesions.

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