Effects of Portal Hypertension on Gadoxetic Acid–Enhanced Liver Magnetic Resonance: Diagnostic and Prognostic Implications

Objective: The aim of this study was to investigate the impact of portal hypertension (PH) on gadoxetic acid–enhanced liver magnetic resonance imaging (MRI) and assess diagnostic and prognostic implications in comparison to established imaging features of PH. Materials and Methods: Institutional review board–approved retrospective study of 178 patients (142 men; median age, 59.4 years) with chronic liver disease undergoing MRI and hepatic venous pressure gradient (HVPG) measurement between January 2008 and April 2015. Magnetic resonance imaging was assessed for established features of PH (splenic and portal vein diameters, portosystemic collaterals, ascites) and for features on 20 minutes delayed T1-weighted gadoxetic acid–enhanced MRI, that is, relative liver enhancement (RLE), biliary contrast excretion, or portal vein hyperintensity or isointensity (ie, portal vein hyperintensity sign, PVHS). Statistics encompassed linear regression, logistic regression, and survival analysis. Results: There was an inverse correlation between HVPG and RLE (r2 = 0.18, P

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