A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer

Summary

Background

Diabetic foot ulcer (DFU) is a devastating complication of diabetes.

Objectives

We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.

Methods

A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.

Results

We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10^-8. The narrow-sense heritability of this phenotype is 0.06.

Conclusions

We suggest that the MAPK14 gene is associated with DFU.

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