Source:Journal of Allergy and Clinical Immunology
Author(s): John D. Widdrington, Aurora Gomez-Duran, Jannetta S. Steyn, Angela Pyle, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Simon V. Baudouin, Anthony J. Rostron, John Simpson, Patrick F. Chinnery FMedSci
Teaser
Monocytes from sepsis patients have mitochondrial DNA (mtDNA) depletion and immune deactivation. Here we find that THP-1 cell immune responses are impaired by experimentally depleting mtDNA, through dysregulated immune signalling, and rescued by interferon-γ treatment.from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2tnwWq2
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